PCOM maintains its main campus in Philadelphia and a branch campus in Suwanee, Georgia area and a location in Moultrie, Georgia.

PCOM the professional resources of a city rich in medical history, achievements and scientific advances are only 15 minutes from the main PCOM campus on City Avenue. This is the seventh site of a college that graduated its first class of two physicians in 1900. It is located on a 17 acre campus that houses four buildings.

The PCOM-Georgia campus occupies 23 acres on Peachtree Road, NW, in Suwanee, Gwinnett County, Georgia. The 172,000 square foot Old Peachtree building features large and small classrooms, conference areas and study spaces. It also houses research and multi-use basic science laboratory, an anatomy laboratory, simulation center, three pharmacy practice labs and a large osteopathic manipulative medicine practice suite.

A second campus building, the 21,000 square foot North lake building, houses offices for administrative personnel, admissions, marketing and communications, human resources and alumni relations. The campus is also home to Georgia osteopathic Care Center, an osteopathic manipulative medicine clinic.

PCOM-South Georgia occupies 31 acres off Tallokas Road in Moultrie, Georgia. The 75,000 square foot, stat of the art facility includes classrooms, an Anatomy lab, an Osteopathic Manipulative Medicine lab, simulation center, small group study rooms, information commons and a café.