The City Avenue site provides a true college campus atmosphere for students, unique among urban medical colleges. All facilities are specially equipped for students with disabilities.

Hassman Academic Center (HAC)
The Howard A. Hassman, DO ’83 Academic Center (formerly known as Evans Hall)—the College’s main building—houses the Zedeck Family and Rose K. Ginsburg amphitheaters, the O.J. Snyder Memorial Library, the Osteopathic Manipulative Medicine Teaching Center, the Gober OMM Practice Room, research labs, anatomy labs and more.

The seven levels of HAC also house the College library, Office of the Provost, Student Affairs, Admissions and Clinical Education. Faculty offices throughout the building are combined with laboratories where faculty, graduates and students pursue instruction and research. The Anatomy Laboratory, which accommodates 250 students simultaneously in the cadaver dissection lab, is recognized as one of the most advanced teaching laboratories in the nation. The architecture of Evans Hall incorporates the teaching of large classes with the enrichment of student-teacher relationships through the use of small classrooms.

HAC is equipped with varied and sophisticated instructional media, exhibit areas and electronic communications equipment. Video monitors are built into the lecture amphitheaters, laboratories and many other teaching areas in the building. The original Evans Hall architecture was enhanced with a three-story addition in 1996. It provides student lounges, study rooms, cafeteria, classrooms, faculty offices, a student computer lab and an osteopathic manipulative medicine teaching center.

The adjacent building—Rowland Hall—is home to the Dr. Michael and Wendy Saltzburg Clinical Learning and Assessment Center, an 11,000-square-foot learning lab designed to help students develop clinical and communication skills through the use of standardized patients and human patient simulators. Rowland Hall also contains the The Angus Gordon Cathie, DO, Collection along with classrooms, study areas, computer labs, student services, academic offices and other support operations.

Other campus facilities include the Levin Administration Building, a 55,000-square-foot activities center and the parking garage.

The campus is also home to the Joseph M. Hassman, DO ’65 Family Medicine Center, one of PCOM's Healthcare Centers which provide treatment to the medically underserved in urban areas of Philadelphia.